This proposal for renewal of the Cancer Center Support Grant (Comprehensive) for the Fred Hutchinson Cancer Research Center of Seattle is to develop support for professional personnel, administration, planning and evaluation, shared resources and services, developmental funds, equipment supplies, clinical oncology units, and community outreach and cancer education programs. Basic Science Programs involving tumor immunology, both basic and clinical, biochemical oncology, carcinogenesis related organic chemistry, medical oncology with various subdivisions, viral oncology, developmental biology, cellular biology, oncologic genetic research, pathology, both clinical and experimental pharmacology. Clinical Programs include a Medical Oncology Unit which has both basic clinical programs with labs, blood separators, diet kitchens (sterile), tissue matching labs, etc., supportive of all aspects of marrow transplantation, clinical and basic studies in treatment of lung, testicular, ovarian cancers and melanomas, pediatric research both basic and clinical in cancer. A neutron project in conjunction with radiation biology as well as a cancer pain research and patient area will occupy the annex. Pediatric research and treatment will be done both at the Center and at Childrens Hospital. Epidemiology and biostatistics programs both in and out of the Center including the SEER and SAQC Programs. Other programs in the Extramural area involve library services, social epidemiology of cancer care, extramural council, rehabilitation medicine. The Center opened September 5, 1975. It has received strong community support from business, labor, the University of Washington, the American Cancer Society, regional and local hospitals and practicing physicians. The Fred Hutchinson Cancer Research Center is functioning as a truly Comprehensive Cancer Center for the Pacific Northwest region.